The inspiration of the artist has constantly changed from prehistoric times to the present day, and artists have revealed events and forms that affect them with various techniques and methods. Artists ' desire to achieve ideal beauty sometimes idealized divine beauty, and sometimes aimed at achieving ideal anatomical forms that take human beauty to the forefront. Artists whose relationship with the ideal beauty has undergone changes in some periods have depicted the ugly, which is sick, bad, incomplete and wrong. In the depictions of the patient, which are the main depictions of the ugly in art, especially figures with body deformation were made. In the historical process, the changing forms and effects of diseases continued to take place in the forms of artists, the pallor of the bodies cursed in the plague epidemic turned into deformation in the bodies of syphilis patients, the deadly effect of Spanish flu affected artists spiritually, form and color were the subject of the works of the period. The image of disease, which is among the unlimited sources of inspiration of the Modern artist, has gained another meaning by the artist's interpretation of ugliness as an aesthetic value. The Modern artist has reinterpreted the deformations and forms whose origins are diseases, the challenge to ideal beauty, leaving aside anatomical rules, the incomplete and deformed ugly state of the body has become an image of beauty recreated in the artist's expression. In our research, historically, the transformation of beauty into ugly in the art of painting was given briefly, the reflection and effects of disease on art forms were mentioned, the transformation of plastic transformations of diseased forms in the works of artists determined by a sample of criteria was examined by evaluating the form and content of disease into ugly aesthetics as an art form.